Operational Diagnostic Criteria in Conjunction with the Triangular Cord Sign Enhance the Screening for Biliary Atresia
ASSOCIATION OF PAEDIATRIC SURGEONS OF BANGLADESH (APSB)
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Abstract
Background: The early and accurate diagnosis of biliary atresia (BA) is critical for timely intervention. The triangular cord sign (TCS) on ultrasonography is a valuable tool, but its diagnostic performance can be variable. Objective: To evaluate whether the use of operational diagnostic criteria (ODC) in conjunction with TCS enhances the screening accuracy for BA. Methods: A prospective cohort study was conducted at MAG Osmani Medical College Hospital, Sylhet in Bangladesh from July 2021 to December 2022. A total of 60 infants with persistent jaundice underwent evaluation for biliary atresia via triangular cord sign, operational diagnostic criteria, and confirmation by intraoperative cholangiography. Data were analyzed with SPSS 23.0. Results: Among 60 infants, biliary atresia was confirmed in 38 (63.3%). The triangular cord sign (TCS) showed 76.3% sensitivity and 86.4% specificity. Operational diagnostic criteria (ODC) alone demonstrated 89.5% sensitivity. Crucially, combining TCS and ODC (positive if either was positive) significantly enhanced sensitivity to 97.4% (p<0.001) with a specificity of 77.3%. The negative predictive value for the combined model was 94.4%, and its AUC of 0.94 was superior to either tool alone. Conclusion: The combination of operational diagnostic criteria with the triangular cord sign creates a highly sensitive and effective screening algorithm for biliary atresia. This integrated approach outperforms either method in isolation and can significantly enhance early detection, timely referral, and ultimately, improve outcomes for infants with this serious condition.
Journal of Paediatric Surgeons of Bangladesh (2023) Vol. 14 (1 & 2): 31–35
