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Journal of Paediatric Surgeons of Bangladesh
Original Articles · Vol. 10 No. 1-2 (2019)

Prognostic value of serum lactate dehydrogenase and serum ferritin for abdominal neuroblastoma in children

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JPSB
Journal of
Paediatric Surgeons of Bangladesh
Published : July 2019
CONTENTSVolume 10Number 1 & 2January - July 2019
Editorial
The risk factors of gall stone formation in children
Md Kabirul Islam
01
Review Articles
Esophageal atresia and tracheoesophageal fistula: A review
Arihant Jain, Nitin James Peters, Shivani Dogra
49
Original Articles
The need for practice enhancements and parental empowerment during their child’s day surgery process: A pilot study
Ahamed Faiz Ali
05
Management of paediatric surgical patients during the COVID-19 pandemic: Our challenges
Mohammed Shadrul Alam, AKM Khairul Basher, Jaglul Gaffer Khan, Muhammed Moinul Huque, Tahmina Hossain, Shahnoor Islam, Samidur Rahman, Kaniz Hasina, Abdul Tablu Hanif, Ashraf Ul Huq
15
Safety and advantages of early oral feeding after intestinal anastomosis in children: Our experience
Refoyez Mahmud, Md Samiul Hasan, Nazmul Islam, Sadia Sultana, Fahim Hasan, Ashrarur Rahman
22
Histopathological study of the fertility components of undescended testes in boys of different age group
Md Mizanur Rahman, A K M Zahid Hossain
26
Comparison between tubularisation of an intact and laterally augmented urethral plate urethroplasty and tubularised incised plate (TIP) urethroplasty for hypospadias repair
Saifuddin Shaheen, Ipsita Biswas, Muhammad Rashedul Alam
32
Result of simple versus layered repair of urethro-cutaneous fistula developing after hypospadias surgery
Amitava Biswas, KM Didarul Islam, Md Ruhul Amin, Agomoni Chaki, AKM Khairul Basher, Md Zamil Hossain
37
Prognostic value of serum lactate dehydrogenase and serum ferritin for abdominal neuroblastoma in children
Dewan Fahmida Akter, Shahnoor Islam
43
Case Reports
Isolated congenital urethrocutaneous fistula: Two case reports
Umme Habiba Dilshad Munmun, A K M Zahid Hossain
62
The Official Journal of the
ASSOCIATION OF PAEDIATRIC SURGEONS OF BANGLADESH (APSB)
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Authors

  • Dewan Fahmida AkterRegistrar, Department of Paediatric Urology, Bangladesh Shishu Hospital & Institute, Dhaka.
  • Shahnoor IslamProfessor, Department of Paediatric Surgery, Dhaka Medical College Hospital, Dhaka

Keywords

Abdominal neuroblastoma Serum lactate dehydrogenase Serum ferritin

Abstract

Backgrounds: For decades, age, MYCN status, stage, and histology have been used as neuroblastoma risk factors. Serum Lactate dehydrogenase (LDH) and ferritin are reproducible, easy to obtain, and prognostic, but they are never used in risk stratification. Purpose/Objective: The purpose of this study was to find out the prognostic value of serum LDH and ferritin in children with abdominal neuroblastoma. Materials/Methods: Nine children with abdominal neuroblastoma from 2020-2021 in four tertiary centers of Dhaka, who treated according to Société Internationale d’Oncologie Pédiatrique selected as study population and divided into low and high-risk groups. Age, sex, stage, histology, serum LDH, serum ferritin and events were analyzed using SPSS 22. Survival was calculated by Kaplan-Meier procedure Results: Sensitivity, specificity, positive predictive value and negative predictive value of serum LDH were 100%, 85.7%, 66.7% and 100% respectively in the prognosis of abdominal neuroblastoma in children at a cut-off point =1527.5. Sensitivity, specificity, positive predictive value, and negative predictive value of serum ferritin were 100%, 71.4%, 50% and 100% respectively in the prognosis of abdominal neuroblastoma in children at a cut-off point=581. There was no significant difference between the survival curves of both risk groups (p= 0.180) and between serum ferritin >581 and ≤581 group (p= 0.089) according to log rank test. But there was significant difference between the survival curves of LDH >1527.5 and LDH ≤1527.5 group according to log rank test (p= 0.027). Conclusion: Analysis of this study revealed that the risk of a worse event for children with abdominal neuroblastoma was greater and outcome was also worse for patients with serum LDH >1527.5 IU/L and serum ferritin >581 ng /ml. These markers can also be used for risk stratification in low to middle income countries. But further multi-centered study with longer period of follow up on larger sample size will be required to demonstrate the independent prognostic value of serum LDH and ferritin for abdominal neuroblastoma in children.

Journal of Paediatric Surgeons of Bangladesh (2019) Vol. 10 (1 & 2): 43–48

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