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Association of Paediatric Surgeons of Bangladesh
Journal of Paediatric Surgeons of Bangladesh
Review Articles · Vol. 7 No. 2 (2016)

Tumor lysis syndrome in paediatric cancer patients

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JPSB
Journal of
Paediatric Surgeons of Bangladesh
Published : July 2016
CONTENTSVolume 07Number 2July 2016
Editorial
Subspeciality or super speciality in paediatric surgery – is it essential or luxury?
Md Tosaddeque Hossain Siddiqui
27
Review Articles
Tumor lysis syndrome in paediatric cancer patients
AKM Amirul Morshed, Shahnoor Islam
55
Original Articles
Interrelationship between food intake & nutritional anaemia among the children studied in a tertiary care hospital in Dhaka city
Md Delwar Hossain, Golam Mowlah, Monira Razzak
29
Nonligation and ligation of hernial sac technique during orchiopexy for palpable undescended testis in children: A comparative study
Md Mahbubul Alam, Partha Sarathy Majumder, Syed Abdul Adil, Md Abdul Aziz, Ashrarur Rahman
35
Serum lead level in children with acute lymphoblastic leukemia
AKM Amirul Morshed, Tasnim Ahmed, Tasrina Rabia Choudhury, Shahnoor Islam
41
Evaluation of the efficacy and safety of intralesional 5- fluorouracil in keloid
Masuda Khatun, M M Abu Sayed
46
The optimal biliary reconstruction for pancreaticobiliary maljunction and congenital biliary dilatation: Clinical comparison between hepaticojejunostomy and hepaticoduodenostomy
Akio Kubota, Yasuyuki Mitani
50
Case Reports
Fetus in fetu with jaundice- A rare presentation of a rare disease
Sifat Zereen Khan, Md Ashraf Ul Huq, Tahmina Hossain, Mohammed Moinul Huque, Syed Md Adil, Sahadeb Kumar Das, H M Zafar Sharif, S M Shafiqul Alam
61
Renal primitive neuroectodermal tumor (RPNET) in children
K M Didarul Islam, Umme Habiba Dilshad Munmun, Shoheli Alam, Noor Mahammad, Md Ruhul Amin, Sanjay Kumar Sah, Shirish Silwal
66
The Official Journal of the
ASSOCIATION OF PAEDIATRIC SURGEONS OF BANGLADESH (APSB)
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Authors

  • AKM Amirul MorshedProfessor and Head, Dept. of Paediatric Haematology & Oncology, Dhaka Medical College Hospital.
  • Shahnoor IslamProfessor, Dept. of Paediatric Surgery, Dhaka Medical College Hospital

Keywords

Tumor Lysis syndrome Children Cancer

Abstract

Introduction: Tumor lysis syndrome (TLS) is a common complication of malignancies and can result in renal failure or death. Review: In paediatric tumor with a high proliferative rate and relatively large mass and a high sensitivity to cytotoxic agents, beging of therapy often results in the rapid release of intracellular metabolic products of proteins and nucleic acids into the bloodstream. Raised concentrations of uric acid, phosphates, potassium and urea can overwhelm the body’s homeostatic mechanisms to excrete these materials and result in the clinical spectrum associated with TLS. Clinical features include gastrointestinal disturbances, neuromuscular effects, cardiovascular complications, acute renal failure and death. The incidence of clinical TLS is approximately 6% for acute leukemias and 10% for lymphomas. Pediatric cancers are the leading cause of death by disease in children. The most common pediatric cancers include the leukemias, lymphoma, Wilms’ tumor and neuroblastoma. Thus, TLS prevention and treatment is a multidisciplinary approach involving the collaboration of medical oncologists/ hematologists and nephrologists has role for optimal patient outcomes. Rehydration is fundamental in the management of TLS. For hyperuricemia we may use allopurinol. Conclusion: The early diagnosis and treatment of metabolic abnormalities prevents the severe complications of tumor lysis syndrome.

Journal of Paediatric Surgeons of Bangladesh (2016) Vol. 7 (2): 55–60

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