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Association of Paediatric Surgeons of Bangladesh
Journal of Paediatric Surgeons of Bangladesh
Original Articles · Vol. 7 No. 2 (2016)

Evaluation of the efficacy and safety of intralesional 5- fluorouracil in keloid

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JPSB
Journal of
Paediatric Surgeons of Bangladesh
Published : July 2016
CONTENTSVolume 07Number 2July 2016
Editorial
Subspeciality or super speciality in paediatric surgery – is it essential or luxury?
Md Tosaddeque Hossain Siddiqui
27
Review Articles
Tumor lysis syndrome in paediatric cancer patients
AKM Amirul Morshed, Shahnoor Islam
55
Original Articles
Interrelationship between food intake & nutritional anaemia among the children studied in a tertiary care hospital in Dhaka city
Md Delwar Hossain, Golam Mowlah, Monira Razzak
29
Nonligation and ligation of hernial sac technique during orchiopexy for palpable undescended testis in children: A comparative study
Md Mahbubul Alam, Partha Sarathy Majumder, Syed Abdul Adil, Md Abdul Aziz, Ashrarur Rahman
35
Serum lead level in children with acute lymphoblastic leukemia
AKM Amirul Morshed, Tasnim Ahmed, Tasrina Rabia Choudhury, Shahnoor Islam
41
Evaluation of the efficacy and safety of intralesional 5- fluorouracil in keloid
Masuda Khatun, M M Abu Sayed
46
The optimal biliary reconstruction for pancreaticobiliary maljunction and congenital biliary dilatation: Clinical comparison between hepaticojejunostomy and hepaticoduodenostomy
Akio Kubota, Yasuyuki Mitani
50
Case Reports
Fetus in fetu with jaundice- A rare presentation of a rare disease
Sifat Zereen Khan, Md Ashraf Ul Huq, Tahmina Hossain, Mohammed Moinul Huque, Syed Md Adil, Sahadeb Kumar Das, H M Zafar Sharif, S M Shafiqul Alam
61
Renal primitive neuroectodermal tumor (RPNET) in children
K M Didarul Islam, Umme Habiba Dilshad Munmun, Shoheli Alam, Noor Mahammad, Md Ruhul Amin, Sanjay Kumar Sah, Shirish Silwal
66
The Official Journal of the
ASSOCIATION OF PAEDIATRIC SURGEONS OF BANGLADESH (APSB)
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Authors

  • Masuda KhatunAssociate Professor, Department of Dermatology & Venereology, Dhaka Medical College, Dhaka
  • M M Abu SayedSenior Consultant, National Institute of Cancer Research and Hospital, Dhaka

Keywords

Intralesional 5- fluorouracil keloid Efficacy

Abstract

Background: Keloid is an area of overgrowth of fibrous tissue that usually develops after healing of skin injury and extends beyond the original defect. The existing treatment modalities include intralesional steroids, cryotherapy, silicone gel sheets, verapamil and 5- fluorouracil (5-FU). Methods: An open label study on 48 keloids in 35 subjects attending the Department of Dermatology in Dhaka Medical College Hospital during June 2017 and November 2017. Patients with keloids of 10cm and less along the longest diameter in the age group 18-75 years, Keloids with signs of infection, History of hypersensitivity and/or intolerance to 5- FU were included in the study. Results: Majority 21(60.0%) patients had single site keloid and 14(40.0%) had multiple site keloid. Majority 54.3% patients had keloids size 2-5 cm. All patients had pain and hyperpigmentation, 5(14.3%) had pustules, 3(8.6%) had necrosis and 1(2.9%) had ulceration. The median keloid area before the treatment was 4 with an inter quartile range of 1.5 to7.8 and this is compared with post treatment area, median 1.5 and inter quartile range 0.6 to 4. Wilcoxon signed rank test was used to assess the reduction in the size of keloid before and after treatment which was significant (P<.001). Conclusion: Majority patients had single site keloid. All patients had pain and hyperpigmentation. low dose intralesional 5-FU is safe and effective modality in the treatment of keloids.

Journal of Paediatric Surgeons of Bangladesh (2016) Vol. 7 (2): 46–49

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