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Association of Paediatric Surgeons of Bangladesh
Journal of Paediatric Surgeons of Bangladesh
Original Articles · Vol. 5 No. 1 (2014)

Comparative study between intralesional Dexamethasone and oral Prednisolone in the treatment of Infantile Hemangioma

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JPSB
Journal of
Paediatric Surgeons of Bangladesh
Published : January 2014
CONTENTSVolume 05Number 1January 2014
Editorial
What we can read and what we cannot read in the mortality curve of the neonatal surgery - the progress of the neonatal surgery in Japan
Akio Kubota
01
Review Articles
Diabetes Mellitus and Gestational Diabetes Mellitus
SA Begum, R Afroz, Q Khanam, A Khanom, TS Choudhury
30
Original Articles
Immediate Outcome of Neonate With Pneumothorax
Marium Begum, Zabrul SM Haque, Mahmuda Hassan, Abdul Mannan, Nasim Jahan
03
Diagnosis of Congenital Anomalies of Kidney and Ureter by Ultrasonography
Fathima Nusrath Halim, Mohammad Ali Sarker, Farah Nazlee, Md Nazrul Islam
08
Comparative study between intralesional Dexamethasone and oral Prednisolone in the treatment of Infantile Hemangioma
Tahmina Akhter Chowdhury, Akbar Husain Bhuiyan, Mohammed Monjurul Hakim
12
Evaluation of breast disease by clinical breast examination (CBE): Experience of a tertiary care hospital
Rehana Akhter, Farzana Deeba, Mir Mosarraf Hossain, Begum Nasreen, Jesmin Banu, Masuma Amanullah
20
A Comparative Study between the Outcome of Laparoscopic Appendectomy and Open Appendectomy in Children
Nazmus Sakib Ferdous, Ashraf Ul Huq, Kaniz Hasina, Masuda Khatun
25
Case Reports
Fetal Hydronephrosis, A Case Report And Review of Literature
Parveen Akhter Shamsunnahar, Abdul Motaleb, Begum Nasrin, Fawzia Hossain, Sharmeen Mahmood, Shirin Akhter Begum
36
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ASSOCIATION OF PAEDIATRIC SURGEONS OF BANGLADESH (APSB)
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Authors

  • Tahmina Akhter ChowdhuryRegistrar, Department of Pediatric Surgery, Chittagong Medical College & Hospital, Chittagong
  • Akbar Husain BhuiyanAssociate Professor, Department of Pediatric Surgery, Chittagong Medical College & Hospital, Chittagong
  • Mohammed Monjurul HakimLecturer, Department of Anatomy, Chittagong Medical College, Chittagong

Keywords

Infantile Hemangioma Intralesional injection of Dexamethasone Oral Prednisolone

Abstract

Background: Infantile Hemangioma (IH) is one of the most common childhood neoplasm. Current treatments for children with endangering Infantile Hemangioma are limited, and include primarily oral corticosteroid which has many systemic adverse effects. Furthermore, approximately one third of IH does not respond to oral steroids, prompting active investigations for new treatments. Objective: To compare the efficacy, side effects, and influencing factors of oral Prednisolone and intralesional Dexamethasone (IL) in treatment of IH and thus to find out an effective, cheap and safe modality of treatment for this anomaly. Materials and Methods: This study was carried out on 48 patients of IH with the age range from 1 day to 12 years. Group A (nā‚=26) patients were treated by oral Prednisolone and group B (nā‚‚=22) patients were treated by IL Dexamethasone. Periorbital Hemangioma and IH >54 cubic centimeter were excluded. Therapeutic response of Prednisolone and Dexamethasone was graded as excellent, good, poor and no response. We monitored volume of the lesion and its color change to evaluate the response to treatment. Results: Overall therapeutic responses were 69.2% in Group A and 68.2% in group B. Side effects were noted in 65.4% patient of group A and 36.4% patient of group B. In group A, the commonest (38.5%) side effect was excessive weight gain with cushingoid facies and in group B, commonest (27.3%) side effect was ulceration at injection site. Side effects were more in children of group A. Range of treatment was 4-20 weeks in group A and in group B, it was 4-24 weeks. Conclusion: IL Dexamethasone is effective as oral Prednisolone for treatment of IH. Unlike Prednisolone, IL Dexamethasone is devoid of systemic side effects.

Journal of Paediatric Surgeons of Bangladesh (2014) Vol. 5 (1): 12–19

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